Author's response to reviews Title: Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer. Authors:
نویسندگان
چکیده
Greg M Arndt ([email protected]) Lesley Dossey ([email protected]) Lara M Cullen ([email protected]) Angela Lai ([email protected]) Riki Druker ([email protected]) Michael Eisbacher ([email protected]) Chunyan Zhang ([email protected]) Nham Tran ([email protected]) Hongtao Fan ([email protected]) Kathy Retzlaff ([email protected]) Anton Bittner ([email protected]) Mitch Raponi ([email protected])
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Investigation of MicroRNA-21 Expression Levels in Serum and Stool as a Potential Non-Invasive Biomarker for Diagnosis of Colorectal Cancer
Background: Most cancer studies focus on exploring non-invasive biomarkers for cancer detection. In the present study, we sought to investigate the expression level of microRNA-21 (miR-21), as a potential diagnostic marker, in serum and stool samples from 40 patients with colorectal cancer (CRC) and 40 healthy controls. Methods: Quantitative real-time RT-PCR was applied to determine the relativ...
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Colorectal cancer (CRC) is one of the most common types of cancers worldwide. Despite the improved therapeutic and diagnostic strategies and screening programs, morbidity and mortality of CRC is still considerable. Currently, most common approaches for diagnosis of CRC are colonoscopy and fecal occult blood test (FOBT). Because of the invasive nature of colonoscopy and low sensitivity of FOBT, ...
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Background and purpose: Colorectal cancer (CRC) is one of the most common types of cancer. Its incidence has increased in Iran during the last 25 years. Micro-RNAs are used as new approach in cancer researches. The roles of miR-146a have been detected in different tumors. This study aimed at investigating the expression of microRNA146 in tumor tissue of colorectal adenocarcinoma in various stag...
متن کاملMicroRNA Expression Profile Reveals miR-17-92 and miR-143-145 Cluster in Synchronous Colorectal Cancer
The expression of abnormal microRNA (miRNA, miR) is a ubiquitous feature of colorectal cancer (CRC). The pathological features and clinical behaviors of synchronous CRC have been comprehensively described; however, the expression profile of miRNA and small nucleolar RNA (snoRNA) in synchronous CRC has not been elucidated. In the present study, the expression profile of miRNA and snoRNA in 5 syn...
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Objective(s):Transforming growth factor-β(TGF-β) is involved in colorectal cancer (CRC). The SD-208 acts as an anti-cancer agent in different malignancies via TGF-β signaling. This work aims to show the effect of manipulation of TGF-β signaling on some miRNAs implicated in CRC. Materials and Methods: We investigated the effects of SD-208 on SW-48, a colon adenocarcinoma cell line. The cell li...
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